Balancing Externalities and Industrial Costs in Air Quality Planning

When adopting regional plans aimed at improving air quality, environmental authorities are often faced with the relevant costs that the adoption of abatement measures implies. On the other hand, scientific literature has well documented damages due to air pollution impact on human health and ecosystems. This paper proposes a tool that allows balancing these two viewpoints by defining the efficient set of measures in a multi-objective perspective. Despite both external (health related) and internal (industrial/emission abatement related) costs can be measured in the same unit, namely money, it appears unacceptable to add them together as in a cost-benefit analysis, since they pertain to quite different social groups. The tool proposed in this paper can thus be seen as a support to actual decision makers and allows them to compare in a ponderable way the pros and cons of any abatement policy. This contrasts what normally happens when air quality health impacts are simply defined as the satisfaction of a constraint at few specific points in space (coincident with the presence of measurement gauges). Indeed, both population and ecosystems are distributed in a non-uniform way on a territory and thus sparse point measurements of pollutant concentrations or other related air quality indicators may be only loosely related with the real impacts of air quality. An application of the tool to a European region (Lombardy, Italy) is presented with particular reference to PM10 and Ozone pollution problems. These are particularly difficult to cope with, since these pollutants are mainly formed in the atmosphere (secondary pollutants) and thus their concentration depends on chemical physical processes involving in different way on one side the emission of precursors and, on the other, the local meteorological conditions.JRC.H.2-Air and Climat

VALIDATION OF MESOSCALE METEOROLOGICAL SIMULATION OVER PO VALLEY FOR AIR QUALITY APPLICATIONS

Very high ground level concentrations of PM in winter and of ozone in summer often occur in Northern Italy, due to the high anthropogenic emissions and frequent stagnant meteorological conditions that characterize the area. These problems are not only related to urban, but also to suburban areas through the entire Po Valley. In such a situation it is important to use deterministic Chemical Transport Models, that allows to evaluate the effect of different air quality control policies on secondary pollution concentrations. Chemical Transport Models generally are part of more complex deterministic modelling systems, encompassing also emission models, meteorological models, and initial and boundary condition processors. Meteorological models are an important module of deterministic modelling systems and, due to their complexity, require high computational costs to perform simulations. In fact they solve a full set of non-hydrostatic equations that describe atmospheric dynamics and thermodynamics, and conservation equations, usually considering two-way interacting nested domains. Within the HPC-EUROPA (Pan-European Research Infrastructure on High Performance Computing) cooperation project, that allows to use clusters of CPUs all around Europe, the meteorological fields over Northern Italy were simulated using RAMS4.4 in parallel mode, creating a database for future air quality assessments. In the present work a CPUs cluster of the Italian computing centre CINECA have been used. The meteorological simulations have been performed considering three nested grids. The first grid covers an area that encompasses the entire Europe, the second grid is focused on Mediterranean sea, while the third one is limited to the Po Valley area. The spatial resolution of the three grids is respectively 128 km, 32 km and 8 km. The number of cells for the three grids is respectively 40x40, 86x86 and 102x102, with 33 vertical levels covering the domain from surface to roughly 20 km height. The entire 2004 year has been simulated through 72 simulations of 126 hours each, considering a spin-up time of 6 hours and 16 CPUs each simulation. In this paper the model configuration and the validation of the simulated meteorological fields are presented

Liquid flow in scaffold derived from natural source: experimental observations and biological outcome

This study investigates the biological effects on a 3D scaffold based on hydroxyapatite cultured with MC3T3 osteoblasts in response to flow-induced shear stress (FSS). The scaffold adopted here (B-HA) derives from the biomorphic transformation of natural wood and its peculiar channel geometry mimics the porous structure of the bone. From the point of view of fluid dynamics, B-HA can be considered a network of micro-channels, intrinsically offering the advantages of a microfluidic system. This work, for the first time, offers a description of the fluid dynamic properties of the B-HA scaffold, which are strongly connected to its morphology. These features are necessary to determine the FSS ranges to be applied during in vitro studies to get physiologically relevant conditions. The selected ranges of FSS promoted the elongation of the attached cells along the flow direction and early osteogenic cell differentiation. These data confirmed the ability of B-HA to promote the differentiation process along osteogenic lineage. Hence, such a bioactive and naturally derived scaffold can be considered as a promising tool for bone regeneration applications

Condition monitoring of the rolling stock and infrastructure: results of a pilot project

The application of Prognostics and Health Monitoring (PHM) concepts in rail vehicles and railway infrastructure is a rapidly growing field of research, and extensive efforts are being spent with the aim of improving the reliability and availability of railway systems and of substantially reducing maintenance costs by switching from time-based to event-driven maintenance policies. This paper presents the results of a research project in which concepts were developed and demonstrated for the health monitoring of the rolling stock (traction equipment) and of the railway infrastructure (track and overhead equipment). A prototype monitoring system was installed on a E464 locomotive and results were gathered across a time span of 14 months from December 2014 to January 2016

A Framework for Integrated Assessment Modelling

“Air quality plans” according to Air Quality Directive 2008/50/EC Art. 23 are the strategic element to be developed, with the aim to reliably meet ambient air quality standards in a cost-effective way. This chapter provides a general framework to develop and assess such plans along the lines of the European Commission’s basic ideas to implement effective emission reduction measures at local, region, and national level. This methodological point of view also allows to analyse the existing integrated approaches

Current Controversies and Challenges on BRAF V600K-Mutant Cutaneous Melanoma

About 50% of melanomas harbour a BRAF mutation. Of these 50%, 10% have a V600K mutation. Although it is the second most common driver mutation after V600E, no specific studies have been conducted to identify a clinical and therapeutic gold standard for this patient subgroup. We analysed articles, including registrative clinical trials, to identify common clinical and biological traits of the V600K melanoma population, including different adopted therapeutic strategies. Melanoma V600K seems to be more frequent in Caucasian, male and elderly populations with a history of chronic sun damage and exposure. Prognosis is poor and no specific prognostic factor has been identified. Recent findings have underlined how melanoma V600K seems to be less dependent on the ERK/MAPK pathway, with a higher expression of PI3KB and a strong inhibition of multiple antiapoptotic pathways. Both target therapy with BRAF inhibitors + MEK inhibitors and immunotherapy with anti-checkpoint blockades are effective in melanoma V600K, although no sufficient evidence can currently support a formal recommendation for first line treatment choice in IIIC unresectable/IV stage patients. Still, melanoma V600K represents an unmet medical need and a marker of poor prognosis for cutaneous melanoma

Prepuberal stimulation of 5-HT7-R by LP-211 in a rat model of hyper-activity and attention-deficit: permanent effects on attention, brain amino acids and synaptic markers in the fronto-striatal interface

The cross-talk at the prefronto-striatal interface involves excitatory amino acids, different receptors, transducers and modulators. We investigated long-term effects of a prepuberal, subchronic 5-HT7-R agonist (LP-211) on adult behaviour, amino acids and synaptic markers in a model for Attention-Deficit/Hyperactivity Disorder (ADHD). Naples High Excitability rats (NHE) and their Random Bred controls (NRB) were daily treated with LP-211 in the 5th and 6th postnatal week. One month after treatment, these rats were tested for indices of activity, non selective (NSA), selective spatial attention (SSA) and emotionality. The quantity of L-Glutamate (L-Glu), L-Aspartate (L-Asp) and L-Leucine (L-Leu), dopamine transporter (DAT), NMDAR1 subunit and CAMKIIα, were assessed in prefrontal cortex (PFC), dorsal (DS) and ventral striatum (VS), for their role in synaptic transmission, neural plasticity and information processing. Prepuberal LP-211 (at lower dose) reduced horizontal activity and (at higher dose) increased SSA, only for NHE but not in NRB rats. Prepuberal LP-211 increased, in NHE rats, L-Glu in the PFC and L-Asp in the VS (at 0.250 mg/kg dose), whereas (at 0.125 mg/kg dose) it decreased L-Glu and L-Asp in the DS. The L-Glu was decreased, at 0.125 mg/kg, only in the VS of NRB rats. The DAT levels were decreased with the 0.125 mg/kg dose (in the PFC), and increased with the 0.250 mg/kg dose (in the VS), significantly for NHE rats. The basal NMDAR1 level was higher in the PFC of NHE than NRB rats; LP-211 treatment (at 0.125 mg/kg dose) decreased NMDAR1 in the VS of NRB rats. This study represents a starting point about the impact of developmental 5-HT7-R activation on neuro-physiology of attentive processes, executive functions and their neural substrates

Human Dental Pulp Stem Cells associated to silk protein scaffold restore critical size bone defects in vivo

The aim of this study is to evaluate potential of fibroin scaffold combined with human dental pulp stem cells (hDPSC) to reconstruct large sized cranial bone defects in animal model. We performed two symmetric full-thickness cranial defects on each parietal region of rats and we replenished them with collagen, poly-D,L-lactic acid (PDLLA) and silk fibroin scaffolds with or without stem cells already seeded into and addressed towards osteogenic lineage in vitro. Animals were euthanized after 4 weeks postoperatively and cranial tissue samples were taken for histological analysis. The presence of human cells in the new bone was confirmed by confocal analysis with an antibody directed to a human mitochondrial protein. We observed a mature bone formation and the most relevant defects correction in constructs with fibroin. Our findings demonstrated the strong potential of bioengineered constructs of stem cells-fibroin scaffold for correcting large cranial defects in animal model and constitutes a promising model for reconstruction of human large cranial defects in craniofacial surgery